Novel High-Drug-Loaded Amorphous Dispersion Tablets of Posaconazole; <i>In Vivo</i> and <i>In Vitro</i> Assessment
Deanna M. Mudie, Aaron M. Stewart, Nishant Biswas, Timothy J. Brodeur, Kimberly B. Shepard, Adam J. Smith, Michael M. Morgen, John M. Baumann, D. Vodak
Abstract
AUC of Noxafil OS compared to the ASD tablets. This study demonstrated that the HLDF approach can increase drug loadings while achieving good performance for ASD drug products.
Topics & Concepts
In vivoPosaconazoleMaterials scienceAmorphous solidDosage formBioavailabilityDispersion (optics)Biomedical engineeringSolubilityChromatographyDissolutionPolymerPharmacologyNanotechnologyChemistryComposite materialMedicineOrganic chemistryItraconazoleDermatologyPhysicsOpticsBiologyBiotechnologyAntifungalDrug Solubulity and Delivery SystemsAdvanced Drug Delivery SystemsAnalytical Methods in Pharmaceuticals