CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD+/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats
Yoshio Ogura, Munehiro Kitada, Jing Xu, Itaru Monno, Daisuke Koya
Abstract
/NADH ratio and Sirt3 activity in renal proximal tubular HK-2 cells cultured under high-glucose conditions. Together, these results demonstrate that by inhibiting the Sirt3 activity and increasing mitochondrial oxidative stress in renal tubular cells, CD38 plays a crucial role in the pathogenesis of DKD.
Topics & Concepts
SIRT3NAD+ kinaseOxidative stressApigeninCD38ChemistryIntracellularMitochondrionSOD2EndocrinologyInternal medicineBiochemistryBiologySirtuinMedicineEnzymeCell biologySuperoxide dismutaseAntioxidantFlavonoidCD34Stem cellCalcium signaling and nucleotide metabolismAdenosine and Purinergic SignalingSirtuins and Resveratrol in Medicine