Engineering synthetic auxotrophs for growth-coupled directed protein evolution
Jiuzhou Chen, Yu Wang, Ping Zheng, Jibin Sun
Topics & Concepts
Directed Molecular EvolutionIn silicoDirected evolutionAuxotrophySynthetic biologyComputational biologyReprogrammingBiologyProtein engineeringSystems biologyProtein expressionMetabolic engineeringSelection (genetic algorithm)Computer scienceCellGeneticsBiochemistryMachine learningGeneEnzymeMutantCRISPR and Genetic EngineeringMicrobial Metabolic Engineering and BioproductionTransgenic Plants and Applications