Sonic Hedgehog/Gli1 Signaling Pathway Regulates Cell Migration and Invasion via Induction of Epithelial-to-mesenchymal Transition in Gastric Cancer
Bin Ke, Xiaona Wang, Ning Liu, Bin Li, Xuejun Wang, Ru-Peng Zhang, Han Liang
Abstract
The aberrant activation of the Sonic hedgehog (Shh) signaling pathway is involved in progression of several types of cancer, including gastric cancer (GC). However, it remains uncertain whether it also plays a critical role in promoting cancer initiation and progression by inducing epithelial-to-mesenchymal transition (EMT) in GC. Thus, the aim of the present study was to determine whether the Shh pathway is involved in GC, and to investigate the function of the Shh pathway in the induction of EMT in GC.
Topics & Concepts
GLI1Sonic hedgehogEpithelial–mesenchymal transitionHedgehog signaling pathwayCancer researchVimentinCyclopamineDownregulation and upregulationBiologyCancerCell migrationSignal transductionImmunohistochemistryMetastasisCell biologyImmunologyCellBiochemistryGeneGeneticsHedgehog Signaling Pathway StudiesEpigenetics and DNA Methylation