Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein
M.W. Day, Sarah Parry-Morris, Jack Houghton-Gisby, Antony W. Oliver, Laurence H. Pearl
Topics & Concepts
PhosphorylationKinaseScaffold proteinCdc25DNA damageCell biologyBiologyProtein kinase ASubstrate-level phosphorylationDNAChemistryBiochemistrySignal transductionCell cycleCellCyclin-dependent kinase 1DNA Repair MechanismsEnzyme Structure and FunctionMicrotubule and mitosis dynamics