An efficient direct phosphinylation and alkylation of ketones to construct C–P and C–C bonds: access to α,α-disubstituted γ-ketophosphine oxides
Xiaohong Wei, Xiaohong Wang, Chun‐Yuan Bai, Ya-Wen Xue, Ping Zhang, Yanbin Wang, Qiong Su
Abstract
The first example of an acid-promoted difunctionalization of ketones to construct C–P and C–C bonds via a phospha-aldol-elimination is described under metal- and solvent-free conditions.
Topics & Concepts
ChemistryAldol reactionConstruct (python library)SolventAlkylationMedicinal chemistryMetalCombinatorial chemistryStereochemistryOrganic chemistryCatalysisComputer scienceProgramming languageAsymmetric Hydrogenation and CatalysisOrganophosphorus compounds synthesisChemical Synthesis and Analysis