Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells
Carmen M. Anadon, Xiaoqing Yu, Kay Hänggi, Subir Biswas, Ricardo A. Chaurio, Alexandra Martin, Kyle K. Payne, Gunjan Mandal, Patrick Innamarato, Carly M. Harro, Jessica A. Mine, Kimberly B. Sprenger, Carla Cortina, John J. Powers, Tara Lee Costich, Bradford A. Perez, Chandler Gatenbee, Sandhya Prabhakaran, Douglas C. Marchion, Mirjam H.M. Heemskerk, Tyler J. Curiel, Alexander R.A. Anderson, Robert M. Wenham, Paulo C. Rodrı́guez, José R. Conejo-García
Abstract
clonotypes), which are primed against high-affinity antigens and maintain waves of effector TRM-like cells. Our results define the signature of relevant tumor-reactive T cells in human ovarian cancer, which could be applicable to other tumors with unideal mutational burden.
Topics & Concepts
Ovarian cancerImmunogenicityBiologyCancer researchProgenitor cellProgenitorCytotoxic T cellCD3ImmunotherapyT-cell receptorT cellCancerImmunologyStem cellAntigenImmune systemCD8Cell biologyGeneticsIn vitroImmune Cell Function and InteractionT-cell and B-cell ImmunologySingle-cell and spatial transcriptomics