Sialyl-LewisX Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy
Florent Colomb, Leila B. Giron, Leticia Kuri-Cervantes, Opeyemi S. Adeniji, Tongcui Ma, Harsh Dweep, Emilie Battivelli, Eric Verdin, Clovis S. Palmer, Hiroaki Tateno, Andrew V. Kossenkov, Nadia R. Roan, Michael R. Betts, Mohamed Abdel‐Mohsen
Abstract
are enriched with markers associated with HIV susceptibility, signaling pathways that drive HIV transcription, and pathways involved in leukocyte extravasation. We describe a glycomic feature of HIV-infected transcriptionally active cells that not only differentiates them from their transcriptionally inactive counterparts but also may affect their trafficking abilities.
Topics & Concepts
Transcription factorBiologyTranscription (linguistics)Leukocyte extravasationIn vivoCellCell biologyIn vitroGlycosylationPhenotypeImmunologyGeneticsGeneLinguisticsPhilosophyHIV Research and TreatmentGlycosylation and Glycoproteins ResearchImmune Cell Function and Interaction