Conversion of Carboxylic Acids to Sulfonamide Bioisosteres via Energy Transfer Photocatalysis
Zhipeng Zong, H. J. Yang, Lulu Yuan, Xiaojie Wang, Jian‐Qiang Chen, Jie Wu
Abstract
More than 450 drugs containing a carboxylic acid functional group have been marketed worldwide. Herein, we report a concise and environmentally friendly organic photoinduced protocol for the interconversion of carboxylic acids into their bioisosteres. With this strategy, a variety of substrates, including alkyl, (hetero)aryl, and alkenyl acids, as well as various biologically relevant acids are successfully converted into primary sulfonamides.
Topics & Concepts
ChemistrySulfonamidePhotocatalysisEnergy transferCombinatorial chemistryOrganic chemistryCatalysisMolecular physicsSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsChemical Synthesis and Reactions