Predominant myosin superrelaxed state in canine myocardium with naturally occurring dilated cardiomyopathy
Julien Ochala, Christopher T. A. Lewis, Thomas Beck, Hiroyuki Iwamoto, Anthony L. Hessel, Kenneth S. Campbell, W. Glen Pyle
Abstract
The key finding of the present study is that, in left ventricles of dogs with a naturally occurring dilated cardiomyopathy, relaxed myosin molecules favor a nonsequestered superrelaxed state potentially impairing sarcomeric contractility. This alteration is rescuable by applying a small molecule activating myosin known as EMD-57033.
Topics & Concepts
Dilated cardiomyopathyCardiologyInternal medicineMyosinMedicineChemistryHeart failureBiochemistryCardiomyopathy and Myosin StudiesCardiovascular Conditions and TreatmentsCardiovascular Effects of Exercise