Left bundle branch pacing <i>vs</i> biventricular pacing in heart failure patients with left bundle branch block: A systematic review and meta-analysis
Farah Yasmin, Abdul Moeed, Rohan Kumar Ochani, Hamna Raheel, Malik Ali Ehtsham Awan, Ayesha Liaquat, Arisha Saleem, Muhammad Aamir, Nael Hawwa, Salim Surani
Abstract
BACKGROUND: Left bundle branch pacing (LBBP) is a novel pacing modality of cardiac resynchronization therapy (CRT) that achieves more physiologic native ventricular activation than biventricular pacing (BiVP). AIM: To explore the validity of electromechanical resynchronization, clinical and echocardiographic response of LBBP-CRT. METHODS: Systematic review and Meta-analysis were conducted in accordance with the standard guidelines as mentioned in detail in the methodology section. RESULTS: In our analysis, the success rate of LBBP-CRT was determined to be 91.1%. LBBP-CRT significantly shortened QRS duration, with significant improvement in echocardiographic parameters, including left ventricular ejection fraction, left ventricular end-diastolic diameter and left ventricular end-systolic diameter in comparison with BiVP-CRT. CONCLUSION: BiVP-CRT group. Lastly, the LBBP-CRT cohort had a reduced pacing threshold at follow-up as compared to BiVP-CRT.