Rational design of metabolically stable HDAC inhibitors: An overhaul of trifluoromethyl ketones
Riddhidev Banerjee, Endri Karaj, Sabitri Lamichhane, Lauren N. Kotsull, Nishanth Kuganesan, Dragan Isailović, Pflum Mary Kay H, Slama James, Taylor William, L. M. Viranga Tillekeratne
Topics & Concepts
ChemistryHistone deacetylaseTrifluoromethylIn vivoHDAC8KetoneIC50EnzymeBiochemistryLead compoundSmall moleculeStructure–activity relationshipStereochemistryHistoneIn vitroOrganic chemistryGeneBiologyAlkylBiotechnologyHistone Deacetylase Inhibitors ResearchSynthetic Organic Chemistry MethodsCatalytic C–H Functionalization Methods