Pyruvate kinase M2 activation reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapy
Seyedeh Sahar Mortazavi Farsani, Jignesh Soni, Jin Lu, Anil Kumar Yadav, Shivani Bansal, Tian Mi, Leena Hilakivi‐Clarke, Robert Clarke, Ben Youngblood, Amrita K. Cheema, Vivek Verma
Topics & Concepts
EffectorMitochondrionCell biologyCD8GlycolysisKinaseBiologyCancer researchChemistryMetabolismBiochemistryImmunologyImmune systemImmune Cell Function and InteractionImmune cells in cancerPhagocytosis and Immune Regulation