Cefiderocol for the Treatment of Infections Due to Metallo-B-lactamase–Producing Pathogens in the CREDIBLE-CR and APEKS-NP Phase 3 Randomized Studies
Jean François Timsit, Mical Paul, Ryan K. Shields, Roger Echols, Takamichi Baba, Yoshinori Yamano, Simon Portsmouth
Abstract
In the CREDIBLE-CR and APEKS-NP studies, cefiderocol treatment was effective against gram-negative bacteria producing metallo-B-lactamases; rates of clinical cure (70.8% [17/24]), microbiological eradication (58.3% [14/24]), and day 28 all-cause mortality (12.5% [3/24]) compared favorably with comparators of best-available therapy and high-dose meropenem (40.0% [4/10], 30.0% [3/10], and 50.0% [5/10], respectively).
Topics & Concepts
MedicineMeropenemGram-negative bacterial infectionsMicrobiologyInternal medicineAntibioticsBiologyAntibiotic resistanceAntibiotic Resistance in BacteriaAntibiotic Use and ResistanceAntibiotics Pharmacokinetics and Efficacy