Determination of best Raman spectroscopy spatial offsets for transcutaneous bone quality assessments in human hands
Keren Chen, Christine Massie, Hani A. Awad, Andrew J. Berger
Abstract
Spatially offset Raman spectroscopy (SORS) is able to detect bone signal transcutaneously and could assist in predicting bone fracture risk. Criteria for optimal source-detector offsets for transcutaneous human measurements, however, are not well-established. Although larger offsets yield a higher percentage of bone signal, the absolute amount of bone signal decreases. Spectral unmixing into bone, adipose, and non-adipose components was employed to quantify changes in bone signal to noise ratio across a range of offsets, and optimal offsets for phalanx and metacarpal measurements were determined. The bone signal to noise ratio was maximized at offsets ranging from 4-6 mm.
Topics & Concepts
Materials scienceBiomedical engineeringSignal-to-noise ratio (imaging)Raman spectroscopyOffset (computer science)Proximal phalanxHuman boneSIGNAL (programming language)AcousticsImage qualityOpticsReproducibilityOsteoporosisNoise (video)RangingSpectroscopyBone matrixSignal processingNuclear medicineAttenuation coefficientSpectroscopy Techniques in Biomedical and Chemical ResearchBone health and osteoporosis researchOptical Imaging and Spectroscopy Techniques