Severe deficiency of the voltage-gated sodium channel NaV1.2 elevates neuronal excitability in adult mice
Jingliang Zhang, Xiaoling Chen, Muriel Eaton, Jiaxiang Wu, Zhixiong Ma, Shirong Lai, Anthony Park, Talha S. Ahmad, Zhefu Que, Ji Hea Lee, Tiange Xiao, Yuansong Li, Yujia Wang, Maria I. Olivero-Acosta, James A. Schaber, Krishna Jayant, Chongli Yuan, Zhuo Huang, Nadia A. Lanman, William C. Skarnes, Yang Yang
Abstract
1.2 deficiency-related seizures.
Topics & Concepts
NAV1Sodium channelChemistryElectrophysiologyInternal medicineEndocrinologySodiumNeuroscienceBiologyMedicineOrganic chemistryNeuroscience and Neuropharmacology ResearchIon channel regulation and functionReceptor Mechanisms and Signaling