In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma
Nelson H. Knudsen, Giulia Escobar, Felix Korell, Tamina Kienka, Celeste Nobrega, Seth Anderson, Andrew Y. Cheng, Maria Zschummel, Alexander Armstrong, Amanda A. Bouffard, Michael C. Kann, Sadie Goncalves, Hans W. Pope, Mitra Pezeshki, Alexánder Rojas, Juliette S. M. T. Suermondt, Merle Phillips, Trisha R. Berger, Sangwoo Park, Diego Salas‐Benito, Elijah P. Darnell, Filippo Birocchi, Mark B. Leick, Rebecca C. Larson, John G. Doench, Debattama R. Sen, Kathleen B. Yates, Robert T. Manguso, Marcela V. Maus
Topics & Concepts
Chimeric antigen receptorT cellBiologyIn vivoCRISPRCell biologyCancer researchCell growthMultiple myelomaCellCD28AntigenCytotoxic T cellEffectorCell cycleB cellImmunotherapyImmunologyT lymphocyteFunction (biology)CytokineCAR-T cell therapy researchCRISPR and Genetic EngineeringViral Infectious Diseases and Gene Expression in Insects