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In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma

Nelson H. Knudsen, Giulia Escobar, Felix Korell, Tamina Kienka, Celeste Nobrega, Seth Anderson, Andrew Y. Cheng, Maria Zschummel, Alexander Armstrong, Amanda A. Bouffard, Michael C. Kann, Sadie Goncalves, Hans W. Pope, Mitra Pezeshki, Alexánder Rojas, Juliette S. M. T. Suermondt, Merle Phillips, Trisha R. Berger, Sangwoo Park, Diego Salas‐Benito, Elijah P. Darnell, Filippo Birocchi, Mark B. Leick, Rebecca C. Larson, John G. Doench, Debattama R. Sen, Kathleen B. Yates, Robert T. Manguso, Marcela V. Maus

2025Nature24 citationsDOIOpen Access PDF

Topics & Concepts

Chimeric antigen receptorT cellBiologyIn vivoCRISPRCell biologyCancer researchCell growthMultiple myelomaCellCD28AntigenCytotoxic T cellEffectorCell cycleB cellImmunotherapyImmunologyT lymphocyteFunction (biology)CytokineCAR-T cell therapy researchCRISPR and Genetic EngineeringViral Infectious Diseases and Gene Expression in Insects
In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma | Litcius