Base-triggerable lauryl sarcosinate–dodecyl sulfate catanionic liposomes: structure, biophysical characterization, and drug entrapment/release studies
Chinapaka Ravindar, S. Thirupathi Reddy, Dokku Sivaramakrishna, Deepthi Priyanka Damera, Musti J. Swamy
Abstract
studies with 5-fluorouracil and rhodamine 6G showed efficient entrapment and release of these two anti-cancer drugs in the physiologically relevant pH range of 6.0-8.0, but with contrasting pH dependences. These observations indicate that LS-DS catanionic vesicles may find application in designing drug delivery systems.
Topics & Concepts
ChemistryIsothermal titration calorimetryDynamic light scatteringSodium dodecyl sulfatePulmonary surfactantVesicleChromatographyMicelleAqueous solutionHydrophobic effectOrganic chemistryChemical engineeringNanoparticleMembranePhysical chemistryBiochemistryEngineeringSurfactants and Colloidal SystemsLipid Membrane Structure and BehaviorMolecular Sensors and Ion Detection