Persistent T cell activation and cytotoxicity against glioblastoma following single oncolytic virus treatment in a clinical trial
Maxime Meylan, Ye Tian, Lijian Wu, Alexander Ling, Daniel Kovarsky, Graham L. Barlow, Linh Dieu Nguyen, Jason W. Pyrdol, Sascha Marx, Lucas Westphal, Julius Michel, L. Nicolas Gonzalez Castro, Sydney Dumont, Andres Santos, Itay Tirosh, Mario L. Suvà, E. Antonio Chiocca, Kai W. Wucherpfennig
Topics & Concepts
Oncolytic virusBiologyCancer researchCytotoxic T cellCytotoxicityImmune systemGranzyme BVirusT cellGranzymeVirotherapyLytic cycleCD8ImmunotherapyImmunityClinical trialInfiltration (HVAC)ImmunologyTumor cellsCellGlioblastomaVirologyTumor-infiltrating lymphocytesRefractory (planetary science)Cell culturePerforinChemotherapyCytolysisT lymphocyteTumor microenvironmentVirus-based gene therapy researchinterferon and immune responsesCancer Research and Treatments