Preparation, Characterization, and Release Behavior of Doxorubicin hydrochloride from Dual Cross-Linked Chitosan/Alginate Hydrogel Beads
Ting Wu, Shaobin Yu, Dongzi Lin, Zhimin Wu, Jun Xu, Jinglin Zhang, Zefen Ding, Ying Miao, Tao Liu, Tao Chen, Xiang Cai
Abstract
toxicity assays indicated that the DOX-loaded CS/SALG hydrogel bead displayed obvious inhibition to tumor cells. These results suggested that the CS/SALG hydrogel bead had the potential application as a colon-targeting oral formulation for DOX transport.
Topics & Concepts
Doxorubicin HydrochlorideChitosanBeadDoxorubicinIn vivoCytotoxicityChemistryIn vitroGlucuronic acidGastric fluidSelf-healing hydrogelsHydrochlorideControlled releaseSodium alginateMaterials scienceSodiumChromatographyBiochemistryNanotechnologyPolymer chemistryChemotherapyPolysaccharideSurgeryOrganic chemistryComposite materialMedicineBiotechnologyBiologyNanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsHydrogels: synthesis, properties, applications