Oligodendroglial glycolipids in (Re)myelination: implications for multiple sclerosis research
Luise Nowack, Charlotte S. Teschers, Stefanie Albrecht, Ryan Gilmour
Abstract
Covering: up to 2020 This short review surveys aspects of glycolipid-based natural products and their biological relevance in multiple sclerosis (MS). The role of isolated gangliosides in disease models is discussed together with an overview of ganglioside-inspired small molecule drugs and imaging probes. The discussion is extended to neurodegeneration in a more general context and addresses the need for more efficient synthetic methods to generate (glyco)structures that are of therapeutic relevance.
Topics & Concepts
GlycolipidRelevance (law)Multiple sclerosisContext (archaeology)NeurodegenerationNeuroscienceComputational biologyGangliosideDiseaseBiologyMedicineImmunologyBiochemistryPolitical sciencePathologyPaleontologyLawSphingolipid Metabolism and SignalingGlycosylation and Glycoproteins ResearchCarbohydrate Chemistry and Synthesis