FcγRIIB potentiates differentiation of myeloid-derived suppressor cells to mediate tumor immunoescape
Lei Wu, Yanquan Xu, Huakan Zhao, Yu Zhou, Yu Chen, Shuai Yang, Juan Lei, Jiangang Zhang, Jingchun Wang, Yongzhong Wu, Yongsheng Li
Abstract
Background: FcRIIB, the sole inhibitory receptor of the Fc gamma receptor family, plays pivotal roles in innate and adaptive immune responses. However, the expression and function of FcRIIB in myeloid-derived suppressor cells (MDSCs) remains unknown. This study aimed to investigate whether and how FcRIIB regulates the immunosuppressive activity of MDSCs during cancer development. Methods: The MC38 and B16-F10 tumor-bearing mouse models were established to investigate the role of FcRIIB during tumor progression. FcRIIB-deficient mice, adoptive cell transfer, mRNA-sequencing and flow cytometry analysis were used to assess the role of FcRIIB on immunosuppressive activity and differentiation of MDSCs.