Epigenetically regulated lncRNAs dissect the intratumoural heterogeneity and facilitate immune evasion of glioblastomas
Dahua Xu, Meng Cao, Bo Wang, Xiaoman Bi, Haiying Zhang, Deng Wu, Chunrui Zhang, Jiankai Xu, Zhizhou Xu, Dehua Zheng, Liyang Chen, Peihu Li, Hong Wang, Yan Liu, Hongyan Jiang, Kongning Li
Abstract
In summary, our study systematically reveals the crosstalk among DNA methylation, lncRNA, and immune regulation in glioblastomas, and will facilitate the development of epigenetic immunotherapy approaches.
Topics & Concepts
Immune systemEpigeneticsGliomaBiologyDNA methylationImmunotherapyCancer researchTranscriptomeImmunologyGeneticsGeneGene expressionCancer-related molecular mechanisms researchRNA modifications and cancerCircular RNAs in diseases