Current Knowledge and Perspectives of Pyrrolizidine Alkaloids in Pharmacological Applications: A Mini-Review
Xianqin Wei, Weibin Ruan, Klaas Vrieling
Abstract
Pyrrolizidine alkaloids (PAs) are a widespread group of secondary metabolites in plants. PAs are notorious for their acute hepatotoxicity, genotoxicity and neurological damage to humans and animals. In recent decades, the application of PAs for beneficial biological activities to cure disease has drawn greater attention. Here, we review the current knowledge regarding the pharmacological properties of PAs and discuss PAs as promising prototypes for the development of new drugs.
Topics & Concepts
PyrrolizidinePyrrolizidine alkaloidDiseaseTraditional medicinePharmacologyMedicineBiologyBioinformaticsInternal medicinePlant Toxicity and Pharmacological PropertiesBotanical Research and Chemistry