Atom-controlled divergent synthesis of spiro and fused rings <i>via</i> base-catalyzed chemoselective annulation
Gang Chen, Guangjie Nie, Linxuan Li, Jie Fu, Hui Yao, Nianyu Huang, Nengzhong Wang
Abstract
Herein, we report a transition metal-free, chemodiverse cycloaddition reaction of azadienes with allylamines for the synthesis of a series of spirobenzofurans, spirotetrandrines, and benzothiophene-diazepines with high diastereoselectivity.
Topics & Concepts
AnnulationChemistryCatalysisBase (topology)Atom (system on chip)Combinatorial chemistryStereochemistryOrganic chemistryParallel computingMathematicsComputer scienceMathematical analysisAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisAsymmetric Synthesis and Catalysis