Aerobic pyruvate metabolism sensitizes cells to ferroptosis primed by GSH depletion
Ana‐Marija Vučković, Rina Venerando, Elena Tibaldi, Valentina Bosello Travain, Antonella Roveri, Luciana Bordin, Giovanni Miotto, Giorgio Cozza, Stefano Toppo, Matilde Maiorino, Fulvio Ursini
Topics & Concepts
SuperoxideChemistryPyruvate dehydrogenase complexLipid peroxidationBiochemistryProgrammed cell deathPyruvate dehydrogenase kinaseGPX4Reactive oxygen speciesMitochondrionCell biologyGlutathioneBiologyOxidative stressApoptosisEnzymeGlutathione peroxidaseFerroptosis and cancer prognosisEpigenetics and DNA MethylationDrug Transport and Resistance Mechanisms