Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Abu Mohammad Syed, Alexander Karius, Jin Ma, Ping-yuan Wang, Paul M. Hwang
Abstract
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disorder of unclear etiology that affects many individuals worldwide. One of its hallmark symptoms is prolonged fatigue following exertion, a feature also observed in long COVID, suggesting an underlying dysfunction in energy production in both conditions. Here, mitochondrial dysfunction and its potential pathogenetic role in these disorders are reviewed.
Topics & Concepts
Chronic fatigue syndromeEncephalomyelitisMedicineEtiologyMotor dysfunctionExertionImmune DysfunctionChronic fatigueImmunologyDiseasePsychiatryPhysical therapyMultiple sclerosisInternal medicineImmune systemFibromyalgia and Chronic Fatigue Syndrome ResearchLong-Term Effects of COVID-19Mitochondrial Function and Pathology