Lung Injury in COVID-19—An Emerging Hypothesis
Abdulrahman Alharthy, Fahad Faqihi, Ziad A. Memish, Dimitrios Karakitsos
Abstract
Lung injury with COVID-19 may be due to a complex underlying pathophysiology. Cytokine release syndrome appears to be a catalyst of different inflammatory pathways promoting lung parenchymal injury and thromboembolic phenomena ("dual hit" injury). Recently, severe neurological manifestations such as acute disseminated encephalomyelitis, which may be not linked to lung pathology, have been identified in COVID-19, contributing thus further to the versatility of its clinical features.
Topics & Concepts
LungCoronavirus disease 2019 (COVID-19)MedicinePathophysiologyDiffuse alveolar damageParenchymaPathologyImmunologyAcute respiratory distressDiseaseInternal medicineInfectious disease (medical specialty)Long-Term Effects of COVID-19COVID-19 Clinical Research StudiesRespiratory Support and Mechanisms