NAD metabolic therapy in metabolic dysfunction-associated steatotic liver disease: Possible roles of gut microbiota
Xinyi Lu, Rui Yang, Yu Chen, Daozhen Chen
Abstract
can not only regulate the level of NAD pool by boosting the carbon metabolism, but also play a vital part in regulating the branched-chain amino acid (BCAA)-related fatty acid metabolism pathway. Altogether, our results support the notion that the gut microbiota contribute to the dietary NAD precursors metabolism in MASLD development and the dietary NAD precursors together with certain gut microbiota may be a preventive or therapeutic strategy in MASLD management.
Topics & Concepts
NAD+ kinaseGut floraNicotinamide adenine dinucleotideFatty liverNicotinamideMetabolismBiologyMechanism (biology)BiochemistryDiseaseMedicineInternal medicineEnzymePhilosophyEpistemologyLiver Disease Diagnosis and TreatmentGut microbiota and healthDiet and metabolism studies