Modulation of brain immune microenvironment and cellular dynamics in systemic inflammation
Junhao Wang, Zhaoqian Zhong, Haihua Luo, Qizheng Han, Kan Xing Wu, Aolin Jiang, Li Chen, Yanxia Gao, Yong Jiang
Abstract
Through dynamic cellular communication networks, the study revealed that, immune dysregulation in the inflamed brain in SAE involves overactivation of innate immunity, with neutrophils playing a crucial role, providing a scientific framework for developing novel therapeutic strategies and offering new insights into the mechanisms underlying sepsis-induced brain dysfunction.
Topics & Concepts
InflammationImmune systemDynamics (music)Immune modulationNeuroscienceSystemic inflammationChemistryCell biologyBiologyImmunologyPhysicsAcousticsTryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsImmune responses and vaccinations