Spicatulides A–G, Phenolic–Monoterpenoid Hybrids from <i>Chloranthus spicatus</i>
Jun‐Su Zhou, Suling Huang, Yuan Gao, Qun‐Fang Liu, Ying Leng, Bin Zhou, Jian‐Min Yue
Abstract
Spicatulides A–G (1–7), seven new phenolic–monoterpenoid hybrid molecules, along with two known compounds, 8 and 9, were isolated and identified from Chloranthus spicatus. Compound 1 represents an unprecedented skeleton featuring an aryl-fused 2-oxabicyclo[4.3.1]decane moiety, and compound 2 is the first example of a denudaquinol–normonoterpenoid adduct. Their structures with absolute configurations were elucidated on the basis of spectroscopic data analyses and TDDFT-ECD calculations. Compounds 3, 5, 6, and 9 exhibited the activity of reducing lipogenesis in HepG2 cells in a dose-dependent manner.
Topics & Concepts
ChemistryStereochemistryMoietyAdductAbsolute configurationArylOrganic chemistryAlkylNatural product bioactivities and synthesisSesquiterpenes and Asteraceae StudiesBioactive Compounds and Antitumor Agents