Hydrogen Sulfide-Induced Vasodilation: The Involvement of Vascular Potassium Channels
Xiaoyu Liu, Lingling Qian, Ruxing Wang
Abstract
Hydrogen sulfide (H 2 S) has been highlighted as an important gasotransmitter in mammals. A growing number of studies have indicated that H 2 S plays a key role in the pathophysiology of vascular diseases and physiological vascular homeostasis. Alteration in H 2 S biogenesis has been reported in a variety of vascular diseases and H 2 S supplementation exerts effects of vasodilation. Accumulating evidence has shown vascular potassium channels activation is involved in H 2 S-induced vasodilation. This review aimed to summarize and discuss the role of H 2 S in the regulation of vascular tone, especially by interaction with different vascular potassium channels and the underlying mechanisms.
Topics & Concepts
VasodilationVascular toneVascular smooth musclePotassium channelHydrogen sulfideHomeostasisPotassiumMedicineChemistryInternal medicinePharmacologySmooth muscleSulfurOrganic chemistrySulfur Compounds in BiologyNitric Oxide and Endothelin EffectsRenin-Angiotensin System Studies