Enantioselective Pictet–Spengler Condensation to Access the Total Synthesis of (+)‐Tabertinggine
Dan Long, Gaoyuan Zhao, Zhiqiang Liu, Peiqi Chen, Shiqiang Ma, Xingang Xie, X. She
Abstract
Abstract A chiral phosphoric acid (CPA)‐catalyzed enantioselective Pictet–Spengler condensation/lactamization cascade reaction was established, which paved the way of the collective synthesis of iboga‐type indole alkaloids. Herein, we presented the asymmetric total synthesis of iboga‐type indole alkaloid (+)‐tabertinggine.
Topics & Concepts
ChemistryEnantioselective synthesisPictet–Spengler reactionIndole testTotal synthesisPhosphoric acidCondensationCascadeCombinatorial chemistryOrganic chemistryStereochemistryCatalysisChromatographyThermodynamicsPhysicsAlkaloids: synthesis and pharmacologyChemical synthesis and alkaloidsTraditional and Medicinal Uses of Annonaceae