RNA localization in confined cells depends on cellular mechanical activity and contributes to confined migration
Rebecca A. Moriarty, Stavroula Mili, Kimberly M. Stroka
Abstract
RNA, we show that peripheral RNA localization contributes to confined cell migration. Our results indicate that a cell's mechanical activity determines its ability to peripherally target RNAs and utilize them for movement in confinement.
Topics & Concepts
Cell biologyMechanosensitive channelsCell migrationRNAMyosinCellCytoskeletonChemistryBiologyGeneIon channelBiochemistryReceptorCellular Mechanics and InteractionsMicrotubule and mitosis dynamicsRNA Research and Splicing