Gastroprotective effects of polysaccharides from purple sweet potato (<i>Ipomoea batatas</i> (L.) Lam) on an ethanol-induced gastric ulcer <i>via</i> regulating immunity and activating the PI3K/Akt/Rheb/mTOR pathway
Hui-Qing Sun, Yinyin Feng, J Zhang, Rui Zhang, Ning Fang, Ziyi She, Liyuan Yun, Meng Meng
Abstract
in the spleen. ELISA analysis showed that the contents of TNF-α, IL-1β and IL-6 were significantly decreased and the content of IL-10 was significantly increased in the PSP group. The western blot analysis showed that PSP could upregulate the relative protein expressions of MUC5AC, PI3K, p-Akt, Rheb and mTOR. These results indicate that PSP can activate the PI3K/Akt/Rheb/mTOR signaling pathway to improve the immunity of mice and maintain the balance of the immune system, thereby protecting the gastric mucosa and improving stress gastric ulcers.
Topics & Concepts
RHEBPI3K/AKT/mTOR pathwayProtein kinase BIpomoeaChemistryPolysaccharideImmune systemImmunityEthanolCancer researchCell biologyBiochemistryBiologySignal transductionBotanyImmunologymTORC1Helicobacter pylori-related gastroenterology studiesPolysaccharides and Plant Cell WallsPhytochemistry and Bioactive Compounds