Hydroxysafflor Yellow A Together with Blood–Brain Barrier Regulator Lexiscan for Cerebral Ischemia Reperfusion Injury Treatment
Liwei Tan, Yeye Wang, Jiang Yu, Rong Wang, Jingzhi Zu, Rui Tan
Abstract
showed that the accumulation of HSYA in the brain could be significantly increased with the addition of Lex. Lastly, HSYA together with Lex (Lex-HSYA) could significantly reduce the volume of cerebral infarction, improve the histopathological morphology, and recruit brain-derived neurotrophic factors to alleviate the cerebral ischemia reperfusion injury. In conclusion, the pyroptosis pathway could act as a novel therapeutic target of HSYA in nerve injury treatment, and Lex-HSYA could be a promising candidate for nerve injury treatments.
Topics & Concepts
PharmacologyNeuroprotectionMedicinePyroptosisReperfusion injuryIschemiaBlood–brain barrierInflammationCentral nervous systemInternal medicineInflammasomeSunflower and Safflower CultivationHeme Oxygenase-1 and Carbon MonoxideSulfur Compounds in Biology