Adipocyte-specific inactivation of NAMPT, a key NAD<sup>+</sup> biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during aging
Nathan Qi, Michael P. Franczyk, Shintaro Yamaguchi, Daiki Kojima, Kaori Hayashi, Akiko Satoh, Noboru Ogiso, Takeshi Kanda, Yo Sasaki, Brian N. Finck, Brian J. DeBosch, Jun Yoshino
Abstract
Defective NAD + metabolism is associated with aging and age-associated metabolic diseases. In the present study, we provided in-depth metabolic assessments in female mice with adipocyte-specific inactivation of a key NAD + biosynthetic enzyme NAMPT and revealed an unexpected role of adipose tissue NAMPT-NAD + -PPAR-γ axis in maintaining functional integrity and quantity of adipose tissue and whole body metabolic health during the aging process.
Topics & Concepts
Nicotinamide phosphoribosyltransferaseEndocrinologyInternal medicineNAD+ kinaseInsulin resistanceBiologyAdipose tissueHyperinsulinemiaNicotinamide adenine dinucleotideAdipocyteWhite adipose tissueMetabolic syndromeEnzymeMedicineDiabetes mellitusBiochemistrySirtuins and Resveratrol in MedicineAdipose Tissue and MetabolismPARP inhibition in cancer therapy