Palladium(II)-Catalyzed Regioselective Hydroesterification of 1,3-Conjugated Enynes with Aryl Formates
Xia-Bin Xiang, Sheng Wang, Xu Teng, Shanshan Chen
Abstract
An effective Pd-catalyzed regioselective hydroesterification of 1,3-conjugated enynes with aryl formates was developed. Under the Pd-CyDPEphos catalytic system, the conjugated enynes reacted with phenyl formates and selectively provided the 2-ester-substituted 1,3-dienes in good yields with excellent regioselectivities.
Topics & Concepts
ChemistryRegioselectivityPalladiumArylCatalysisConjugated systemOrganic chemistryMedicinal chemistryCombinatorial chemistryPolymerAlkylCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsSynthetic Organic Chemistry Methods