The Toxicity of Protein Aggregates: New Insights into the Mechanisms
Alessandra Bigi, Eva Lombardo, Roberta Cascella, Cristina Cecchi
Abstract
The aberrant aggregation of specific peptides and proteins is the common feature of a range of more than 50 human pathologies, collectively referred to as protein misfolding diseases [...].
Topics & Concepts
ToxicityChemistryProtein aggregationComputational biologyBiologyBiochemistryOrganic chemistryEndoplasmic Reticulum Stress and DiseaseAlzheimer's disease research and treatmentsProtein purification and stability