Enzyme-like catalysis by single chain nanoparticles that use transition metal cofactors
Thao M. Xiong, Edzna Garcia, Junfeng Chen, Lingyang Zhu, Ariale J. Alzona, Steven C. Zimmerman
Abstract
We report a modular approach in which a noncovalently cross-linked single chain nanoparticle (SCNP) selectively binds catalyst "cofactors" and substrates to increase both the catalytic activity of a Cu-catalyzed alkyne-azide cycloaddition reaction and the Ru-catalyzed cleavage of allylcarbamate groups compared to the free catalysts.
Topics & Concepts
CatalysisAlkyneCofactorChemistryCycloadditionCombinatorial chemistryCleavage (geology)NanoparticleEnzymeAzideNanotechnologyOrganic chemistryMaterials scienceComposite materialFracture (geology)Click Chemistry and ApplicationsMolecular Junctions and NanostructuresNanocluster Synthesis and Applications