Age and sex dependency of thoracic aortopathy in a mouse model of Marfan syndrome
Nazli Gharraee, Yujian Sun, Joseph A. Swisher, Susan M. Lessner
Abstract
Male Fbn-1 C1041G/+ mice show more severe thoracic aortic changes compared with females, especially at 12 mo of age. Up to 6 mo of age, Sca-1 + smooth muscle progenitor cells are more abundant in the adventitia of both male and female Fbn-1 Het mice compared with wild types (WTs). Male and female Het mice show similar patterns of expression of Sca-1 + cells at early ages.
Topics & Concepts
Marfan syndromeDependency (UML)MedicineInternal medicineComputer scienceSoftware engineeringConnective tissue disorders researchAortic Disease and Treatment ApproachesCardiovascular Issues in Pregnancy