Recent advances in aza Friedel–Crafts reaction: strategies for achiral and stereoselective synthesis
Ameni Hadj Mohamed, Nicolas Masurier
Abstract
The aza-Friedel–Crafts (aza-FC) reaction is a very powerful tool for forming C–C and C–N bonds, based on an acid-catalyzed addition of electron-rich aromatic compounds to imines.
Topics & Concepts
Friedel–Crafts reactionChemistryStereoselectivityOrganic chemistryCombinatorial chemistryCatalysisAsymmetric Synthesis and CatalysisChemical Synthesis and AnalysisSynthesis of Indole Derivatives