The influence of Gd-DOTA conjugating ratios to PLGA-PEG micelles encapsulated IR-1061 on bimodal over-1000 nm near-infrared fluorescence and magnetic resonance imaging
Doan Thi Kim Dung, Masakazu Umezawa, Kazunobu Ohnuki, Karina Nigoghossian, Kyohei Okubo, Masao Kamimura, Masayuki Yamaguchi, Hirofumi Fujii, Kohei Soga
Abstract
contrast enhancement effects on MRI. Moreover, it demonstrated bright OTN-NIR fluorescence and MRI contrast enhancement to depict veins and observe the organs in live mice. The imaging results revealed that the Gd-DOTA introduction ratio is of great importance for controlling the biological response of the probe without reducing the contrast enhancement effect.
Topics & Concepts
FluorescenceMicelleMagnetic resonance imagingEthylene glycolFluorescence-lifetime imaging microscopyMaterials scienceNuclear magnetic resonanceNear-infrared spectroscopyPLGAChemistryNanotechnologyNanoparticleOpticsPhysicsPhysical chemistryOrganic chemistryRadiologyMedicineAqueous solutionNanoplatforms for cancer theranosticsPhotoacoustic and Ultrasonic ImagingOptical Imaging and Spectroscopy Techniques