Catalytic Enantioselective Methylene C(sp<sup>3</sup>)–H Hydroxylation Using a Chiral Manganese Complex/Carboxylic Acid System
Qiangsheng Sun, Wei Sun
Abstract
, and a carboxylic acid in 2,2,2-trifluoroethanol. The benzylic alcohols were successfully furnished in excellent diastereoselectivities (up to >95:5) and enantioselectivities (up to 95% ee). As a highlight of this work, high diastereoselectivity of C-H hydroxylation could be achieved by tuning the amount of carboxylic acid additive.
Topics & Concepts
Enantioselective synthesisChemistryHydroxylationStereoselectivityManganeseCatalysisCarboxylic acidMethyleneOrganic chemistryCombinatorial chemistryStereochemistryEnzymeMetal-Catalyzed Oxygenation MechanismsOxidative Organic Chemistry ReactionsCatalytic C–H Functionalization Methods