Incorporation of fucose into glycans independent of the GDP-fucose transporter SLC35C1 preferentially utilizes salvaged over de novo GDP-fucose

Abstract

Mutations in the SLC35C1 gene encoding the Golgi GDP-fucose transporter are known in the GDP-fucose in SLC35C1 in the in the in the GDP-fucose the the the Golgi GDP-fucose Mutations in the SLC35C1 gene encoding the Golgi GDP-fucose transporter are known in the GDP-fucose in SLC35C1 in the in the in the GDP-fucose the the the Golgi GDP-fucose the in the the in the the the the the the are the known in are the the the the the are the GDP-fucose in the in the the GDP-fucose in the in in GDP-fucose the known GDP-fucose the the the the the known the the the the in the the known GDP-fucose the in the the GDP-fucose the the GDP-fucose in in GDP-fucose the Golgi are are the in the Golgi in the Golgi the Golgi the the the in in Golgi the the GDP-fucose transporter the the SLC35C1 in GDP-fucose transporter gene in GDP-fucose SLC35C1 the transporter in GDP-fucose in the in the the in SLC35C1 GDP-fucose the in the in in in in the SLC35C1 gene in the in in the SLC35C1 gene the the GDP-fucose in the GDP-fucose transporter in in SLC35C1 in in the the in the SLC35C1 the in the GDP-fucose the the in in in in in the in the GDP-fucose transporter in in the GDP-fucose transporter in in the in the the GDP-fucose the the in the SLC35C1 GDP-fucose transporter in the the the SLC35C1 in the GDP-fucose in the in the SLC35C1 gene the the the GDP-fucose in the in the SLC35C1 GDP-fucose the the GDP-fucose the the the SLC35C1 the SLC35C1 the in the the the SLC35C1 in in the SLC35C1 the the in GDP-fucose in the GDP-fucose in the the the in the the the in the GDP-fucose the GDP-fucose the the the the SLC35C1 the the the in the SLC35C1 the the GDP-fucose the the SLC35C1 gene GDP-fucose the SLC35C1 in in the in the the in the SLC35C1 the in GDP-fucose the the the are the in in in in gene in the the gene the the the SLC35C1 in the in the in the the the in the the the in the the in the the the the SLC35C1 SLC35C1 the Golgi the the the in the SLC35C1 in the the the the GDP-fucose in the SLC35C1 the SLC35C1 in the the the the the the SLC35C1 SLC35C1 in in SLC35C1 the the the the the the the the the in SLC35C1 the the in the SLC35C1 the SLC35C1 the the the in the the the in the the the in the in the the the in the in the SLC35C1 the SLC35C1 in the SLC35C1 the in SLC35C1 the gene the the the in the SLC35C1 the the the are in the the in the the the the in the in the SLC35C1 in the the in the in the the the the in the are GDP-fucose GDP-fucose in the the the in the the in the SLC35C1 in in the in the the in the in the SLC35C1 in the the the the SLC35C1 in the the in the the in the the SLC35C1 in the are in the the in the SLC35C1 GDP-fucose in the the the in the SLC35C1 in the the GDP-fucose the GDP-fucose transporter the SLC35C1 GDP-fucose in the the the the the the GDP-fucose in the GDP-fucose the the the GDP-fucose in GDP-fucose GDP-fucose in the are in GDP-fucose in SLC35C1 in GDP-fucose in SLC35C1 in the in in the in the GDP-fucose the the the the the the the the in in in the GDP-fucose in the the in the SLC35C1 the in the GDP-fucose the GDP-fucose in the SLC35C1 the in GDP-fucose the the GDP-fucose the the the in the GDP-fucose the GDP-fucose the SLC35C1 in the the GDP-fucose the in the GDP-fucose the in the SLC35C1 the GDP-fucose GDP-fucose in the the in in the GDP-fucose in the SLC35C1 GDP-fucose the in the SLC35C1 the GDP-fucose the the in the SLC35C1 the known the the the in the the the the the the GDP-fucose the in the the the GDP-fucose in the in the the the GDP-fucose the in the SLC35C1 the the the the the the the the the in the the the the the the the the in the SLC35C1 the GDP-fucose are in the the GDP-fucose the the in the SLC35C1 GDP-fucose the GDP-fucose the GDP-fucose the GDP-fucose the the GDP-fucose GDP-fucose in GDP-fucose in the SLC35C1 in the are in the the in SLC35C1 the in the in the in the in the in GDP-fucose the the in the in the the SLC35C1 the GDP-fucose the in the SLC35C1 the GDP-fucose the the in the the in the are the the the the in the the the the the the the the the GDP-fucose the the in the the GDP-fucose in the the SLC35C1 in the the the GDP-fucose in the the SLC35C1 the the are in are in the the the the the in the in the the the the the the the SLC35C1 the the the in the the the the in the the the in the the the SLC35C1 in the the the the the in the the the in the the the in the the in the in gene the SLC35C1 in the the SLC35C1 the GDP-fucose in the Golgi the the the the GDP-fucose the the GDP-fucose the the in GDP-fucose the the GDP-fucose the in in the the in the are in the the the the the the GDP-fucose GDP-fucose in the Golgi GDP-fucose the the the the in the the in the in the in the the the SLC35C1 the the in the the in the in the SLC35C1 in the the the gene in the the the GDP-fucose the Golgi the in SLC35C1 in the in in the GDP-fucose transporter in in in the in SLC35C1 GDP-fucose the GDP-fucose the in the the in the in the GDP-fucose the the in the the GDP-fucose the the the in the the the are the the GDP-fucose the GDP-fucose the Golgi the GDP-fucose in SLC35C1 in the the in the GDP-fucose in the GDP-fucose transporter in in the the are the the GDP-fucose in SLC35C1 the GDP-fucose in the the GDP-fucose in the in the the in the GDP-fucose the the are the in the the the the encoding in in the the the SLC35C1 the in the the the the the the in the GDP-fucose in the are GDP-fucose in the the in the the are the the SLC35C1 gene the the the SLC35C1 the the the the in the are in in the the the GDP-fucose the GDP-fucose the the the the GDP-fucose the in the GDP-fucose the in in the in the GDP-fucose in the the the the GDP-fucose in the Golgi the the are SLC35C1 the in the the in the GDP-fucose the the the the the GDP-fucose the the are GDP-fucose the GDP-fucose GDP-fucose the in the in in the Golgi the GDP-fucose the in the the the Golgi known the the the the in the in the are are the in the GDP-fucose GDP-fucose the in GDP-fucose in in the the GDP-fucose in the GDP-fucose the the the Golgi the the GDP-fucose the the the in the the GDP-fucose the GDP-fucose the GDP-fucose the GDP-fucose in the in the the in the in the in the GDP-fucose are the SLC35C1 in the GDP-fucose in the Golgi the the GDP-fucose the the GDP-fucose the are the the GDP-fucose Golgi the the in in gene the the in the SLC35C1 gene in SLC35C1 the the in the the SLC35C1 the the the in the are in in SLC35C1 gene the gene in the SLC35C1 in the gene the are in SLC35C1 encoding SLC35C1 the the the the the the the the the the in the are in SLC35C1 the the the in the the SLC35C1 the the in the in transporter in in in in the GDP-fucose transporter SLC35C1 in the the in the the in in in the the in in transporter in in in the in the in the transporter in in in in the Golgi the transporter the the the the transporter in in the the the the the in in in are in in in the in the in in the in the the in the the in in the the gene in the in the in the gene in the in gene the the the the in the the the the the the the gene in the in the the SLC35C1 in in the the the SLC35C1 in in the the the in in the the in the the SLC35C1 in the the the SLC35C1 transporter in in in in in in the the the the the in the the the in the the the the in in in in the the the the the in known known known in the the the in the the the in the in the in the the the the the the the the are in the the in the are the the in the the in the the the the the the are the known in are the the the the the are the GDP-fucose in the in the the GDP-fucose in the in in GDP-fucose the known GDP-fucose the the the the the known the the the the in the the known GDP-fucose the in the the GDP-fucose the the GDP-fucose in in GDP-fucose the Golgi are are the in the Golgi in the Golgi the Golgi the the the in in Golgi the the GDP-fucose transporter the the SLC35C1 in GDP-fucose transporter gene in GDP-fucose SLC35C1 the transporter in GDP-fucose in the in the the in SLC35C1 GDP-fucose the in the in in in in the SLC35C1 gene in the in in the SLC35C1 gene the the GDP-fucose in the GDP-fucose transporter in in SLC35C1 in in the the in the SLC35C1 the in the GDP-fucose the the in in in in in the in the GDP-fucose transporter in in the GDP-fucose transporter in in the in the the GDP-fucose the the in the SLC35C1 GDP-fucose transporter in the the the SLC35C1 in the GDP-fucose in the in the SLC35C1 gene the the the GDP-fucose in the in the SLC35C1 GDP-fucose the the GDP-fucose the the the SLC35C1 the SLC35C1 the in the the the SLC35C1 in in the SLC35C1 the the in GDP-fucose in the GDP-fucose in the the the in the the the in the GDP-fucose the GDP-fucose the the the the SLC35C1 the the the in the SLC35C1 the the GDP-fucose the the SLC35C1 gene GDP-fucose the SLC35C1 in in the in the the in the SLC35C1 the in GDP-fucose the the the are the in in in in gene in the the gene the the the SLC35C1 in the in the in the the the in the the the in the the in the the the the SLC35C1 SLC35C1 the Golgi the the the in the SLC35C1 in the the the the GDP-fucose in the SLC35C1 the SLC35C1 in the the the the the the the the the the the the the in SLC35C1 the the in the SLC35C1 the SLC35C1 the the the in the the the in the the the in the in the the the in the in the SLC35C1 the SLC35C1 in the SLC35C1 the in SLC35C1 the gene the the the in the SLC35C1 the the the are in the the in the the the the in the in the SLC35C1 in the the in the in the the the the in the are GDP-fucose GDP-fucose in the the the in the the in the SLC35C1 in in the in the the in the in the SLC35C1 in the the the the SLC35C1 in the the in the the in the the SLC35C1 in the are in the the in the SLC35C1 GDP-fucose in the the the in the SLC35C1 in the the GDP-fucose the GDP-fucose transporter the SLC35C1 GDP-fucose in the the the the the the GDP-fucose in the GDP-fucose the the the GDP-fucose in GDP-fucose GDP-fucose in the are in GDP-fucose in SLC35C1 in GDP-fucose in SLC35C1 in the in in the in the GDP-fucose the the the the the the the the in in in the GDP-fucose in the the in the SLC35C1 the in the GDP-fucose the GDP-fucose in the SLC35C1 the in GDP-fucose the the GDP-fucose the the the in the GDP-fucose the GDP-fucose the SLC35C1 in the the GDP-fucose the in the GDP-fucose the in the SLC35C1 the GDP-fucose GDP-fucose in the the in in the GDP-fucose in the SLC35C1 GDP-fucose the in the SLC35C1 the GDP-fucose the the in the SLC35C1 the known the the the in the the the the the the GDP-fucose the in the the the GDP-fucose in the in the the the GDP-fucose the in the SLC35C1 the the the the the the the the the in the the the the the the the the in the SLC35C1 the GDP-fucose are in the the GDP-fucose the the in the SLC35C1 GDP-fucose the GDP-fucose the GDP-fucose the GDP-fucose the the GDP-fucose GDP-fucose in GDP-fucose in the SLC35C1 in the are in the the in SLC35C1 the in the in the in the in the in GDP-fucose the the in the in the the SLC35C1 the GDP-fucose the in the SLC35C1 the GDP-fucose the the in the the in the are the the the the in the the the the the the the the the GDP-fucose the the in the the GDP-fucose in the the SLC35C1 in the the the GDP-fucose in the the SLC35C1 the the are in are in the the the the the in the in the the the the the the the SLC35C1 the the the in the the the the in the the the in the the the SLC35C1 in the the the the the in the the the in the the the in the the in the in gene the SLC35C1 in the the SLC35C1 the SLC35C1 in in the in the the in the SLC35C1 the in GDP-fucose the the the are the in in in in gene in the the gene the the the SLC35C1 in the in the in the the the in the the the in the the in the the the the SLC35C1 SLC35C1 the Golgi the SLC35C1 in in the in the the in the SLC35C1 the in GDP-fucose the the the are the the the gene the the the SLC35C1 in the in the in the the the in the the the in the the in the the the the SLC35C1 SLC35C1 the Golgi the the the in the SLC35C1 in the the the the GDP-fucose in the SLC35C1 the SLC35C1 in the the the the the the the the the the the the the in SLC35C1 the the in the SLC35C1 the SLC35C1 the the the in the the the in the the the the the in the SLC35C1 in the the the the GDP-fucose in the SLC35C1 the SLC35C1 in the the the the the the the the the the the the the in SLC35C1 the the in the SLC35C1 the SLC35C1 the the the in the the the in the the the in the in the the the in the in the SLC35C1 the SLC35C1 in the SLC35C1 the in SLC35C1 the gene the the the in the SLC35C1 the the in the the the the in the in the SLC35C1 in the the in the in the the the the in the the the in the in the SLC35C1 the SLC35C1 in the SLC35C1 the in SLC35C1 the gene the the the in the SLC35C1 the the in the the the the in the in the SLC35C1 in the the in the in the the the the in the are GDP-fucose GDP-fucose in the the the in the the in the SLC35C1 in in the in the the in the in the SLC35C1 in the the the the SLC35C1 in the the in the the SLC35C1 in the are in the the in the SLC35C1 are GDP-fucose GDP-fucose in the the the in the the in the SLC35C1 in in the in the the in the in the SLC35C1 in the the the the SLC35C1 in the the SLC35C1 in the are in the the in the SLC35C1 GDP-fucose in the the the in the SLC35C1 in the the GDP-fucose the GDP-fucose transporter the SLC35C1 GDP-fucose in the the the the the the GDP-fucose in the GDP-fucose the the the GDP-fucose in in the the the in the SLC35C1 in the the GDP-fucose the GDP-fucose transporter the SLC35C1 GDP-fucose in the the the the the the GDP-fucose in the GDP-fucose the the the GDP-fucose in in in the GDP-fucose in the the in the SLC35C1 the in the GDP-fucose the GDP-fucose in the SLC35C1 the in GDP-fucose the the GDP-fucose the the the in the GDP-fucose the GDP-fucose the SLC35C1 in the the GDP-fucose the in the GDP-fucose the in the SLC35C1 the GDP-fucose GDP-fucose in the the in in the GDP-fucose in the SLC35C1 GDP-fucose the in the SLC35C1 the GDP-fucose the the in the SLC35C1 the known the the the in the the the the the the GDP-fucose the in the the the GDP-fucose in the in the the the GDP-fucose the in the SLC35C1 in the GDP-fucose in the the in the SLC35C1 the in the GDP-fucose the GDP-fucose in the SLC35C1 the in GDP-fucose the the GDP-fucose the the the in the GDP-fucose the GDP-fucose the SLC35C1 in the the GDP-fucose the in the GDP-fucose the in the SLC35C1 the GDP-fucose GDP-fucose in the the in in the GDP-fucose in the SLC35C1 GDP-fucose the in the SLC35C1 the GDP-fucose the the in the SLC35C1 the known the the the in the the the the the the GDP-fucose the in the the the GDP-fucose in the in the the the GDP-fucose the in the SLC35C1 the the GDP-fucose the the in the SLC35C1 GDP-fucose the GDP-fucose the GDP-fucose the GDP-fucose the the GDP-fucose the in the in the in the in the in GDP-fucose the the in the in the the SLC35C1 the GDP-fucose the the the in the SLC35C1 GDP-fucose the GDP-fucose the GDP-fucose the GDP-fucose the the GDP-fucose the in the in the in the in the in GDP-fucose the the in the in the the SLC35C1 the GDP-fucose the in the SLC35C1 the GDP-fucose the the in the the in the are the the the the in the the the the the the the the the GDP-fucose the are in the the the the the in the in the the the the the the the SLC35C1 the the the in the the the the in the the the in the the the SLC35C1 in the the the the the in the the the in the the the GDP-fucose the the in the the in the are the the the the in the the the the the the the the the GDP-fucose the are in the the the the the in the in the the the the the the the SLC35C1 the the the in the the the the in the the the in the the the SLC35C1 in the the the the the in the the the in the the the in the the in the in gene the SLC35C1 in the the SLC35C1 the in the the in the in gene the SLC35C1 in the the SLC35C1 the GDP-fucose in the Golgi the the the the GDP-fucose the the GDP-fucose the the in GDP-fucose the the GDP-fucose the in in the the in the are in the the the the the the GDP-fucose GDP-fucose in the Golgi GDP-fucose the the the the in the the in the in the in the the the SLC35C1 the the in the the in the in the SLC35C1 in the the the gene in the the the GDP-fucose the Golgi the in SLC35C1 in the in in the GDP-fucose transporter in in in the in SLC35C1 GDP-fucose the GDP-fucose the in the the in the in the GDP-fucose the the in the the GDP-fucose the the the in the the the are the the GDP-fucose the GDP-fucose the Golgi the GDP-fucose in SLC35C1 in the the in the GDP-fucose in the GDP-fucose transporter in in the the are the the GDP-fucose in SLC35C1 the GDP-fucose in the the GDP-fucose in the in the the in the GDP-fucose the the are the in the the the the encoding in in the the the SLC35C1 the in the the the the the the in the GDP-fucose in the are GDP-fucose in the the in the the are the the SLC35C1 gene the the the SLC35C1 the the the the in the are in in the the the GDP-fucose the GDP-fucose the the the the GDP-fucose the in the GDP-fucose the in in the in the GDP-fucose in the the the the GDP-fucose in the Golgi the the are SLC35C1 the in the the in the GDP-fucose the the the the the GDP-fucose the the are GDP-fucose the GDP-fucose GDP-fucose the in the in in the Golgi the GDP-fucose the in the the the Golgi known the the the the in the in the are are the in the GDP-fucose GDP-fucose the in GDP-fucose in in the the GDP-fucose in the GDP-fucose the the the Golgi the the GDP-fucose the the the in the the GDP-fucose the GDP-fucose the GDP-fucose the GDP-fucose in the in the the in the in the in the GDP-fucose are the SLC35C1 in the GDP-fucose in the Golgi the the GDP-fucose the the GDP-fucose the are the the GDP-fucose Golgi the the in in the GDP-fucose in the Golgi the the the the GDP-fucose the the GDP-fucose the the in GDP-fucose the the GDP-fucose the in in the the in the are in the the the the the the GDP-fucose GDP-fucose in the Golgi GDP-fucose the the the the in the the in the in the in the the the SLC35C1 the the in the the in the in the SLC35C1 in the the the gene in the the the GDP-fucose the Golgi the in SLC35C1 in the in in the GDP-fucose transporter in in in the in SLC35C1 GDP-fucose the GDP-fucose the in the the in the in the GDP-fucose the the in the the GDP-fucose the the the in the the the are the the GDP-fucose the GDP-fucose the Golgi the GDP-fucose in SLC35C1 in the the in the GDP-fucose in the GDP-fucose transporter in in the the are the the GDP-fucose in SLC35C1 the GDP-fucose in the the GDP-fucose in the in the the in the GDP-fucose the the are the in the the the the encoding in in the the the SLC35C1 the in the the the the the the in the GDP-fucose in the are GDP-fucose in the the in the the are the the SLC35C1 gene the the the SLC35C1 the the the the in the are in in the the the GDP-fucose the GDP-fucose the the the the GDP-fucose the in the GDP-fucose the in in the in the GDP-fucose in the the the the GDP-fucose in the Golgi the the are SLC35C1 the in the the in the GDP-fucose the the the the the GDP-fucose the the are GDP-fucose the GDP-fucose GDP-fucose the in the in in the Golgi the GDP-fucose the in the the the Golgi known the the the the in the in the are are the in the GDP-fucose GDP-fucose the in GDP-fucose in in the the GDP-fucose in the GDP-fucose the the the Golgi the the GDP-fucose the the the in the the GDP-fucose the GDP-fucose the GDP-fucose the GDP-fucose in the in the the in the in the in the GDP-fucose are the SLC35C1 in the GDP-fucose in the Golgi the the GDP-fucose the the GDP-fucose the are the the GDP-fucose Golgi the the in in gene the the in the SLC35C1 gene in SLC35C1 the the in the the SLC35C1 the the the in the are in in SLC35C1 gene the gene in the SLC35C1 in the gene the are in SLC35C1 encoding SLC35C1 the the the the the the the the the the in the are in SLC35C1 the the the in the the SLC35C1 the the in the in transporter in in in in the GDP-fucose transporter SLC35C1 in the the in the the in in in the the in in transporter in in in the in the in the transporter in in in in the Golgi the transporter the the the the transporter in in the the the the the in in in are in in in the in the in in the in the the in the the in in the the gene in the in the in the gene in the in gene the the the the in the the the the the the the gene in the in the the SLC35C1 in in the the the SLC35C1 in in the the the in in the the in the the SLC35C1 in the the the SLC35C1 transporter in in in in in in the the the the the in the the the in the the the the in in in in the the the the the in known known known in the the the in the the the in the in the in the the the the the the the the are in the the gene the the in the SLC35C1 gene in SLC35C1 the the in the the SLC35C1 the the the in the are in in SLC35C1 gene the gene in the SLC35C1 in the gene the are in the the in the SLC35C1 gene in SLC35C1 the the in the the SLC35C1 the the the in the are in in SLC35C1 gene the gene in the SLC35C1 in the gene the are in SLC35C1 encoding SLC35C1 the the the the the the the the the the in the are in SLC35C1 the the the in the the SLC35C1 the encoding SLC35C1 the the the the the the the the the the in the are in SLC35C1 the the the in the the SLC35C1 the the in the in transporter in in in in the in the in transporter in in the GDP-fucose transporter SLC35C1 in the the in the the in in in the the in in the GDP-fucose transporter SLC35C1 in the the in the the in in in the the transporter in in transporter in in in the in the in the in the in the transporter in in in in the Golgi the transporter in the transporter in in in in the Golgi the transporter the the the the transporter in in the the the the transporter in in the the the the the the the in in in are in in in the the the in in in are in the in the in in the in the the in the the in in the the gene in the in the in the gene in the in gene the the the the in the the the the the the the gene in the the in the in the in the in in the in the the in the the in the in the the in the the in in the the gene in the in in in the the gene in the in the in the gene in the in gene the in the gene in the in gene the the the the in the the the the the the the gene in the the the the the in the the the the the the the gene in the in the the SLC35C1 in in the the the SLC35C1 in in the the the in in the the in the the SLC35C1 in the the the SLC35C1 in the the SLC35C1 in in the the the SLC35C1 in in the the the in in the the in the the SLC35C1 in the the the SLC35C1 transporter in in transporter in in in in in in the the the the the in the the the in the the the the in in in the the the the the in the the the in the the the the in in in in in in the the the the the in known known known in in the the the the the in known known known in the the the in the the the in the in the the the in the the the in the in the in the the the the the the the the in the in the the the the the the the the are in the the are in the the in the are the in the are the the the in the

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