Accelerated developmental adipogenesis programs adipose tissue dysfunction and cardiometabolic risk in offspring born to dams with metabolic dysfunction
Anna Mikolajczak, Nada A. Sallam, Radha Dutt Singh, Taylor B. Scheidl, Emma Walsh, Sebastian Larion, Carol Huang, Jennifer Thompson
Abstract
This study reveals that accelerated adipogenesis during the perinatal window of adipose tissue development predisposes to later life hypertrophic adipocyte dysfunction, thereby compromising the buffering function of the subcutaneous depot.
Topics & Concepts
AdipogenesisOffspringAdipose tissueEndocrinologyMedicineInternal medicineObesityMetabolic syndromeBiologyPregnancyGeneticsBirth, Development, and HealthAdipose Tissue and MetabolismObesity, Physical Activity, Diet