Mass spectrometry imaging of free-floating brain sections detects pathological lipid distribution in a mouse model of Alzheimer's-like pathology
Štěpán Strnad, Veronika Pražienková, Martina Holubová, David Sýkora, Josef Cvačka, Lenka Maletı́nská, Blanka Železná, Jaroslav Kuneš, Vladimír Vrkoslav
Abstract
The applicability of paraformaldehyde-fixed free-floating sections for the MALDI MSI of lipids was studied and the developed procedure was used for studying lipid changes in a mouse model of Alzheimer's pathology.
Topics & Concepts
ParaformaldehydePathologyMass spectrometry imagingPathologicalDistribution (mathematics)Mass spectrometryLipidomicsLipid metabolismChemistryMedicineBiochemistryChromatographyMathematicsMathematical analysisMetabolomics and Mass Spectrometry StudiesAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research