Design, synthesis and in silico insights of new 7,8-disubstituted-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione derivatives with potent anticancer and multi-kinase inhibitory activities
Abdalla R. Mohamed, Ahmed M. El Kerdawy, Riham F. George, Hanan H. Georgey, Nagwa M. Abdel Gawad
Topics & Concepts
ADMEChemistryIn silicoKinaseDocking (animal)In vitroIC50Purine analogueStereochemistryPurineLigand efficiencyCombinatorial chemistryEnzymeBiochemistryLigand (biochemistry)ReceptorGeneNursingMedicineQuinazolinone synthesis and applicationsSynthesis and biological activityPI3K/AKT/mTOR signaling in cancer