Facile access to 4′-(<i>N</i>-acylsulfonamide) modified nucleosides and evaluation of their inhibitory activity against SARS-CoV-2 RNA cap <i>N</i>7-guanine-methyltransferase nsp14
Romain Amador, Adrien Delpal, Bruno Canard, Jean‐Jacques Vasseur, Étienne Decroly, Françoise Debart, Guillaume Clavé, Michaël Smietana
Abstract
4′-( N -Acylsulfonamide) adenosine derivatives have been efficiently synthetized via the sulfo-click reaction and their biological activity has been evaluated as potential inhibitors of the SARS-CoV-2 RNA cap N 7-guanine- methyltransferase nsp14.
Topics & Concepts
ChemistrySulfonamideSynthonMoietyGuanineNucleosideAcylationRNAStereochemistryMethyltransferaseCombinatorial chemistryBiochemistryNucleotideDNACatalysisMethylationGeneHIV/AIDS drug development and treatmentCRISPR and Genetic EngineeringSulfur-Based Synthesis Techniques