Ruthenium‐Catalyzed C7‐Formylmethylation or Sequential Acetalization of Indolines with Vinylene Carbonate in Different Solvents
Min Liu, Kelu Yan, Jiangwei Wen, Wenda Shang, Xinlei Sui, Xiu Wang
Abstract
Abstract The ruthenium‐catalyzed C7‐formylmethylation or sequential acetalization of indolines with vinylene carbonate has been realized under simple and easy‐to‐operate reaction systems. Several preliminary mechanistic studies and derivatization reactions for the conversion of formylmethyl group were also performed. This transformation offers an alternative approach for the direct conversion of C( sp 2 )−H to formylmethyl or corresponding acetal structure. magnified image
Topics & Concepts
RutheniumChemistryDerivatizationCatalysisAcetalCarbonateCombinatorial chemistryOrganic chemistryHigh-performance liquid chromatographyCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisCarbon dioxide utilization in catalysis